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C-type lectin
InterPro Domain

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. The C-type designation is from their requirement for calcium for binding. Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.

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Classification

Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.5 This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).6 Most recently, three further subgroups were added (XV to XVII).7

GroupNameAssociated domains
ILecticansEGF, Sushi, Ig and Link domains
IIAsialoglycoprotein and DC receptorsNone
IIICollectinsNone
IVSelectinsSushi and EGF domains
VNK - cell receptorsNone
VIMulti-CTLD endocytic receptorsFnII and Ricin domains
VIIReg groupNone
VIIIChondrolectin, LayilinNone
IXTetranectinNone
XPolycystinWSC, REJ, PKD domains
XIAttractin (ATRN)PSI, EGF and CUB domains
XIIEosinophil major basic protein (EMBP)None
XIIIDGCR2None
XIVThrombomodulin, CD93, CD248, CLEC14AEGF domains 8
XVBimlecNone
XVISEECSCP and EGF domains
XVIICBCP/Frem1/QBRICKCSPG repeats and CalX-beta domains

CLECs include:

The "NK Cell lectin-like receptors" are a very closely related group:9

Additional proteins containing this domain include:

References

  1. Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259. S2CID 7084402. /wiki/Doi_(identifier) ↩

  2. C-Type+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) https://meshb.nlm.nih.gov/record/ui?name=C-Type+Lectin ↩

  3. Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765. /wiki/Doi_(identifier) ↩

  4. Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. Bibcode:2009CBio...19.R375C. doi:10.1016/j.cub.2009.03.032. PMID 19439262. S2CID 17409821. https://doi.org/10.1016%2Fj.cub.2009.03.032 ↩

  5. Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 45: 207–32. doi:10.1016/S0079-6603(08)60870-3. ISBN 978-0-12-540045-9. PMID 8341801. 978-0-12-540045-9 ↩

  6. Drickamer K, Fadden AJ (2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp. 69 (69): 59–72. doi:10.1042/bss0690059. PMID 12655774. /wiki/Doi_(identifier) ↩

  7. Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259. S2CID 7084402. /wiki/Doi_(identifier) ↩

  8. Khan, K. A.; McMurray, J. L.; Mohammed, F.; Bicknell, R. (2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC 6852297. PMID 31287944. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852297 ↩

  9. NK+Cell+Lectin-Like+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) https://meshb.nlm.nih.gov/record/ui?name=NK+Cell+Lectin-Like+Receptors ↩