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Carl Djerassi
American chemist and writer (1923–2015)

Carl Djerassi (October 29, 1923 – January 30, 2015) was an Austrian-born Bulgarian-American pharmaceutical chemist, novelist, playwright and co-founder of Djerassi Resident Artists Program with Diane Wood Middlebrook. He is best known for his contribution to the development of oral contraceptive pills, nicknamed the "father of the pill".

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Early life

Carl Djerassi was born in Vienna, Austria, but spent the first years of his infancy in Sofia, Bulgaria, the home of his father, Samuel Djerassi, a dermatologist and specialist in sexually transmitted diseases.56 His mother was Alice Friedmann, a Viennese dentist and physician. Both parents were Jewish.7

Following his parents' divorce, Djerassi and his mother moved to Vienna. Until the age of 14, he attended the same realgymnasium that Sigmund Freud had attended many years earlier;8 spending summers in Bulgaria with his father.9

Austria refused him citizenship and after the Anschluss, his father briefly remarried his mother in 1938 to allow Carl and his mother to escape the Nazi regime and flee to Sofia, Bulgaria, where he lived with his father for a year.10 Bulgaria, although not immune to antisemitism, proved a safe haven, as the country managed to save its entire 48,000-strong Jewish population from deportation to Nazi concentration camps. During his time in Sofia, Djerassi attended the American College of Sofia where he became fluent in English.11

In December 1939, Djerassi arrived with his mother in the United States, nearly penniless. Djerassi's mother worked in a group practice in upstate New York.12 In 1949, his father emigrated to the United States,13 practiced in Pennsylvania and West Virginia, and eventually retired near his son in San Francisco, California.

Education

Djerassi started his college career at Newark Junior College after moving to the United States with his mother when he was 16. He previously had attended the American College of Sofia, a high school in Sofia, Bulgaria, where he became fluent in English. Because of the name of his high school, he was misunderstood and enrolled into Newark Junior College before graduating high school. After a year at Newark Junior College, Djerassi wrote a letter to First Lady Eleanor Roosevelt asking for help with a room and board and tuition scholarship to a four-year college. He received a response from the Institute of International Education with a full scholarship to Tarkio College where he briefly attended, and then studied chemistry at Kenyon College, where he graduated summa cum laude.141516 After one year at CIBA, he moved to the University of Wisconsin–Madison where he earned his PhD in organic chemistry in 1945.17 His thesis work examined the transformation of the male sex hormone testosterone into the female sex hormone estradiol, through a sequence of chemical reactions.18

Career

In 1942/43, Djerassi worked for CIBA in New Jersey, developing Pyribenzamine19 (tripelennamine), his first patent and one of the first commercial antihistamines.2021

In 1949 Djerassi became associate director of research at Syntex in Mexico City and remained there through 1951.22 He has said that one factor influencing him to choose Syntex was that they had a DU spectrophotometer.23 He worked on a new synthesis of cortisone based on diosgenin, a steroid sapogenin derived from a Mexican wild yam.24 His team later synthesized norethisterone (norethindrone),25 the first highly active progestin analogue that was effective when taken by mouth. This became part of one of the first successful combined oral contraceptive pills, known colloquially as the birth-control pill, or simply, the Pill. From 1952 to 1959 he was professor of chemistry at Wayne State University in Detroit.26

Djerassi participated in the invention in 1951, together with Mexican Luis E. Miramontes and Hungarian-Mexican George Rosenkranz, of the progestin norethisterone—which, unlike progesterone, remained effective when taken orally and was far stronger than the naturally occurring hormone. His preparation was first administered as an oral contraceptive to animals by Gregory Goodwin Pincus and Min Chueh Chang and to women by John Rock.27

In 1957, he became vice president of research at Syntex in Mexico City while on leave of absence from Wayne State. In 1960 Djerassi became a professor of chemistry at Stanford University,28 a position he held until 2002 29 but only part-time as he never left industry.30 From 1968 until 1972 he also served as president of Syntex Research at Palo Alto.31

The Syntex connection brought wealth to Djerassi. He bought a large tract of land in San Mateo County, California, and started a cattle ranch called SMIP. (Initially an acronym for "Syntex Made It Possible", other variants have been suggested since.) He also assembled a large art collection. His collection of works by Paul Klee was considered to be one of the most significant to be privately held.3233 He arranged for his Klee collections to be donated to the Albertina in Vienna and the San Francisco Museum of Modern Art, effective on his death.34

Throughout the 1960s and 1970s, Djerassi continued to do significant scientific work, as a professor in the department of chemistry at Stanford University, and as an entrepreneur. He pioneered novel physical research techniques for mass spectrometry and optical rotatory dispersion and applied them to the areas of organic chemistry and the life sciences.35 Focusing on the steroid hormones and alkaloids, he elucidated the structure of steroids, an area in which he published over 1,200 papers.36 His scientific interests were wide-ranging, and his technological achievements include work in instrumentation, pharmaceuticals, insect control, the application of artificial intelligence in biomedical research, and the biology and chemistry of marine organisms.37

In 1968, he started a new company, Zoecon,38 which focused on environmentally soft methods of pest control, using modified insect growth hormones to stop insects from metamorphosing from the larval stage to the pupal and adult stages.39 Zoecon was eventually acquired by Occidental Petroleum, which later sold it to Sandoz, now Novartis. Part of Zoecon survives in Dallas, Texas, making products to control fleas and other pests.

In 1965 at Stanford University, nobel laureate Joshua Lederberg, computer scientist Edward Feigenbaum, and Djerassi devised the computer program DENDRAL (dendritic algorithm) for the elucidation of the molecular structure of unknown organic compounds taken from known groups of such compounds, such as the alkaloids and the steroids.40 This was a prototype for expert systems and one of the first uses of artificial intelligence in biomedical research.41

Djerassi was a member of the Board of Sponsors of the Bulletin of the Atomic Scientists42 and was chairman of the Pharmanex Scientific Advisory Board.43

Publications

Djerassi published widely as a novelist, playwright and scientist.44454647 In 1985, Djerassi said "I feel like I'd like to lead one more life. I'd like to leave a cultural imprint on society rather than just a technological benefit."4849 He went on to write several novels in the "science-in-fiction" genre, including Cantor's Dilemma,50 in which he explored the ethics of modern scientific research through his protagonist, Dr. Cantor. He also wrote four autobiographies, the most recent of which, In Retrospect appeared in 2014.51 He wrote a number of plays which have been performed and extensively translated.5253 His book Chemistry in Theatre: Insufficiency, Phallacy or Both discusses the potential pedagogic value of using dialogic style and the plot structure of plays with special focus on chemistry.54

Science-in-fiction

Djerassi wrote five novels, four of which he described as "science-in-fiction",5556 fiction that portrays the lives of real scientists, with all their accomplishments, conflicts, and aspirations. The genre is also referred to as Lab lit.57

In his first two novels, Cantor's Dilemma and Bourbaki Gambit, he shows how scientists work and think. In Cantor's Dilemma, there is the suspicion of scientific fraud; in Bourbaki Gambit the question of personal achievement stands in the center.58 In the third, Menachem's Seed, ICSI and the Pugwash organization are the main themes.59 In the last, NO, he shows how young scientists develop an idea as far as founding a company to market a product60 – something Djerassi himself did in the field of insecticides.

The topic of the fifth novel, Marx Deceased, is the role of a writer's earlier bestsellers for the assessment of a new work – in contrast to the assessment of an anonymous work or one of a formerly unknown author.61 He also plays with this topic in Bourbaki Gambit.

Science-in-theatre

After his success with prose literature in the Science-in-Fiction genre, Djerassi started to write plays.62 Theatre, even more so than prose, seemed to fulfill his desire to work in a more “dialogical” environment than the monological natural sciences had allowed him to do.63 According to British director Andy Jordan, who has produced all of his plays in England, Djerassi's dramatic works are "not wholly or straightforwardly naturalistic or realistic […but] avowedly text-driven, where ideas, themes, words and language were majorly important, a fact I had always to be conscious of as the director.264

Djerassi's first play, An Immaculate Misconception (1998), dealing with the in vitro fertilization procedure ICSI,65 was followed by two plays about priority struggles in the history of science, Oxygen (co-authored with Roald Hoffmann, 1999)66 and Calculus (2002),67 and a drama at the intersection of chemistry and art history, Phallacy (2004).68 Ego (2003, also produced under the title Three on a Couch),69 together with the docudrama Four Jews on Parnassus (2006, publ. 2008)70 and Foreplay (2010),71 are the only three dramatic pieces that do not deal with science-in-literature but rather carry the notion of intellectual competitiveness into literature, philosophy and the humanities. Taboos (2006), a complex play between reproductive, gender and political issues, returns to Djerassi's central concerns as a scientist;72 his 2012 play Insufficiency is a bitter satire of both the scientific community and academic environments.73 ICSI, sex in the age of mechanical reproduction (2002), was taken to theaters and also to classrooms as a pedagogic wordplay, in many countries, including Spain and Argentina (by collaboration with Dr Àgata Baizán and Alberto Diaz) where it opened the VIII Latinoamerican and Caribbean Biotechnology meeting REDBIO-Argentina 2013 and featured in universities and theaters.74

As in his novels, Djerassi's plays incorporate the life and achievements of (sometimes famous) scientists as well as new scientific technologies. The science in his plays is always scientifically plausible although the dramatic personae and locations are fictitious.75 By placing scientists and research into dramatic worlds, he raises critical questions about the sciences as cultural systems and looks into internal conflicts and contradictions in science and between scientists.76 The constant competition between them, the need for priority in new scientific discoveries even if the required speed necessitates risky and immoral means, as well as the problematic consequences of new discoveries are important topics of the plays.

Connected with many of these questions is the role of women in the sciences (including researchers’ wives and female friends). Djerassi's plays recognize the special contributions women make as scientists and to science, both directly and indirectly. His female characters are usually depicted as strong and independent, proving a strong impact of feminist thinking on his work.77

Djerassi's plays have found their way into theaters around the globe and have been translated into many European and Asian languages.78 Djerassi repeatedly revised his plays and some of them have different versions and multiple endings79 (especially An Immaculate Misconception: the nationalities of the main characters vary, also the endings). Where possible, Djerassi also cooperated with directors in the production of dramatic performances.80 All of his plays have been published in book form, many of them in a number of languages. Some of them can be downloaded from his website.

Poetry

Djerassi wrote numerous poems that were published in journals or anthologies. Some of the poems reflected his life as a chemist (e.g. Why are chemists not poets or The clock runs backwards), others his personal life (e.g. A Diary of Pique).818283

Non-fiction

  • Optical Rotatory Dispersion, McGraw-Hill & Company, 1960.
  • The Politics of Contraception84
  • Steroids Made it Possible85
  • The Pill, Pygmy Chimps, and Degas' Horse86
  • From the Lab into The World: A Pill for People, Pets, and Bugs87
  • Paul Klee: Masterpieces of the Djerassi Collection88
  • Dalla pillola alla penna89
  • This Man's Pill: Reflections on the 50th Birthday of the Pill90
  • In Retrospect : From the Pill to the Pen91

Fiction

  • Cantor's Dilemma, 1989929394
  • The Bourbaki Gambit, 1994959697
  • The Futurist and Other Stories98
  • How I Beat Coca-Cola and Other Tales of One-Upmanship99
  • Marx, Deceased. A Novel, 1996100
  • Menachem's Seed. A Novel, 1997101
  • NO. A Novel, 1998102

Drama

  • Chemistry in Theatre: Insufficiency, Phallacy or Both103
  • Foreplay: Hannah Arendt, the Two Adornos, and Walter Benjamin104
  • Four Jews on Parnassus
  • An Immaculate Misconception: Sex in an Age of Mechanical Reproduction105
    • L.A. Theatre Works106
  • Oxygen (with Roald Hoffmann, coauthor)107
  • Newton's Darkness: Two Dramatic Views108
  • Sex in an Age of Technological Reproduction: ICSI and TABOOS109 translated to Spanish and brought to scene by Dr. Àgata Baizán110

Awards and honors

Djerassi won numerous awards during his career including:

An award that eluded Djerassi was the Nobel Prize, where he is considered one of the more notable "snubs" by the Nobel Committee.129

Personal life

Djerassi described himself as a "Jewish atheist".130

Djerassi was married three times and had two children. He and Virginia Jeremiah were married in 1943 and divorced in 1950.131 Djerassi married writer Norma Lundholm (1917–2006) later that year.132 They had two children together, and were divorced in 1976.133 One year after his second divorce, Djerassi began a relationship with Diane Middlebrook, a Stanford University professor of English and biographer.134 In 1985, they were married and they lived between San Francisco and London, until her death on December 15, 2007, due to cancer.135136

On July 5, 1978, Djerassi's artist daughter Pamela (born 1950; from his second marriage, to Norma Lundholm), committed suicide,137138 which is described in his autobiography. With Middlebrook's help, Djerassi then considered how he could help living artists, rather than collecting works of dead ones. He visited existing artist colonies, such as Yaddo and MacDowell, and decided to create his own, the Djerassi Resident Artists Program.139140 He closed his cattle ranch and converted the barn and houses to residential and work space for artists.141142 He and his wife moved to a high rise in San Francisco that they had renovated.

Carl Djerassi died on January 30, 2015, at the age of 91, from complications of liver and bone cancer.143144 Upon his death he was survived by his son and grandson.

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References

  1. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

  2. Ball P (2015) "Carl Djerassi", Nature 519(7541), 34. /wiki/Nature_(journal) ↩

  3. Zare, R. N. (2015). "Carl Djerassi (1923-2015)". Angewandte Chemie International Edition. 54 (17): 5001–5002. doi:10.1002/anie.201501335. PMID 25809781. https://doi.org/10.1002%2Fanie.201501335 ↩

  4. Joachim Haupt (2008). Mein Leben – Carl Djerassi, der Vater der Pille (in German). ZDF, Arte. 43 minutes in. Archived from the original on February 20, 2017. Retrieved February 19, 2017. https://web.archive.org/web/20170220092708/http://www.arte.tv/guide/de/039500-000-A/mein-leben-carl-djerassi-der-vater-der-pille ↩

  5. "Carl Djerassi, father of the Pill – obituary", The Telegraph, February 2, 2015. https://www.telegraph.co.uk/news/obituaries/11384755/Carl-Djerassi-father-of-the-Pill-obituary.html ↩

  6. Weintraub, Bob. "Pincus, Djerassi and Oral Contraceptives", Chemistry in Israel, Bulletin of the Israel Chemical Society. August 2005, pp. 47–50. https://drive.google.com/file/d/1y_30HHlitenXG4rNMEtViLW1YbOOXy6a_OND_nD_5z-0tAjAjB-EyGT9PS-m/edit ↩

  7. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

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  10. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

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  12. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

  13. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

  14. "A Conversation with Carl Djerassi". Youtube.com. Annual Reviews. 13 April 2012. Retrieved 2022-03-27. https://www.youtube.com/watch?v=OVL8FKitRLM ↩

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  20. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

  21. Ball P (2015) "Carl Djerassi", Nature 519(7541), 34. /wiki/Nature_(journal) ↩

  22. Sturchio, Jeffrey L.; Thackray, Arnold (July 31, 1985). Carl Djerassi, Transcript of an Interview Conducted by Jeffrey L. Sturchio and Arnold Thackray at Stanford University on July 31, 1985 (PDF). Philadelphia, PA: Center for History of Chemistry. https://oh.sciencehistory.org/sites/default/files/djerassi_c_0017_suppl.pdf ↩

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  25. Djerassi, C.; Miramontes, L.; Rosenkranz, G.; Sondheimer, F. (1954). "Steroids. LIV.1Synthesis of 19-Nov-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone2". Journal of the American Chemical Society. 76 (16): 4092–4094. Bibcode:1954JAChS..76.4092D. doi:10.1021/ja01645a010. /wiki/Bibcode_(identifier) ↩

  26. Sturchio, Jeffrey L.; Thackray, Arnold (July 31, 1985). Carl Djerassi, Transcript of an Interview Conducted by Jeffrey L. Sturchio and Arnold Thackray at Stanford University on July 31, 1985 (PDF). Philadelphia, PA: Center for History of Chemistry. https://oh.sciencehistory.org/sites/default/files/djerassi_c_0017_suppl.pdf ↩

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  29. Arnold, Laurence (January 31, 2015). "Carl Djerassi, Chemist Behind Birth-Control Pill, Dies at 91". Bloomberg. https://www.bloomberg.com/news/articles/2015-01-31/carl-djerassi-chemist-behind-birth-control-pill-dies-at-91 ↩

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  32. Wood, Gaby (April 14, 2007). "Father of the pill". The Guardian. Retrieved February 4, 2015. https://www.theguardian.com/lifeandstyle/2007/apr/15/healthandwellbeing.features1 ↩

  33. "Djerassi Resident Artists Program". Archived from the original on February 14, 2015. Retrieved February 4, 2015. https://web.archive.org/web/20150214174510/http://djerassi.org/programhistory.html ↩

  34. "Albertina's Modern Holdings Deepened by Transfer of Batliner Collection". Art Tattler International. Archived from the original on February 4, 2015. Retrieved February 4, 2015. https://web.archive.org/web/20150204193917/http://arttattler.com/archivemodernmasterworks.html ↩

  35. Reinhardt, Carsten. "CHF Remembers Carl Djerassi". Chemical Heritage Foundation. Archived from the original on March 21, 2015. Retrieved February 2, 2015. https://web.archive.org/web/20150321044501/http://blog.distillations.org/post/109905137147/chf-remembers-carl-djerassi ↩

  36. Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html ↩

  37. Reinhardt, Carsten. "CHF Remembers Carl Djerassi". Chemical Heritage Foundation. Archived from the original on March 21, 2015. Retrieved February 2, 2015. https://web.archive.org/web/20150321044501/http://blog.distillations.org/post/109905137147/chf-remembers-carl-djerassi ↩

  38. Sturchio, Jeffrey L.; Thackray, Arnold (July 31, 1985). Carl Djerassi, Transcript of an Interview Conducted by Jeffrey L. Sturchio and Arnold Thackray at Stanford University on July 31, 1985 (PDF). Philadelphia, PA: Center for History of Chemistry. https://oh.sciencehistory.org/sites/default/files/djerassi_c_0017_suppl.pdf ↩

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  44. Gehrke, Ingrid (2008). Der intellektuelle Polygamist: Carl Djerassi's Grenzgänge in Autobiographie, Roman und Drama. Berlin et al.: Lit Verlag. ISBN 978-3-8258-1444-1. 978-3-8258-1444-1 ↩

  45. Grünzweig, Walter, ed. (2012). The SciArtist: Carl Djerassi's Science-in-Literature in Transatlantic and Interdisciplinary Contexts. Berlin et al.: Lit Verlag. ISBN 978-3-643-90231-3. 978-3-643-90231-3 ↩

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