List of unsolved problems may refer to several notable conjectures or open problems in various academic fields:
Natural sciences, engineering and medicine
- Unsolved problems in astronomy
- Unsolved problems in biology
- Unsolved problems in chemistry
- Unsolved problems in geoscience
- Unsolved problems in medicine
- Unsolved problems in neuroscience
- Unsolved problems in physics
Mathematics, statistics and information sciences
- Unsolved problems in mathematics
- Unsolved problems in statistics
- Unsolved problems in computer science
- Unsolved problems in information theory