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Current prescription combination drugs

For more common combination drugs, see WHO Model List of Essential Medicines.

The combination drugs listed below are typically available by prescription only, but specific circumstances regarding a given combination's legal accessibility, or any specific regulation pertinent to ingredient quality, quantities, production standards, sourcing, etc. will vary by jurisdictions, and include:

• amitriptyline (tricyclic antidepressant/TCA) combined with perphenazine (typical antipsychotic), branded Triavil
• amitriptyline and chlordiazepoxide (benzodiazepine), Limbitrol, available in India and Bangladesh
• amlodipine (calcium channel blocker) and benazepril ([CE inhibitor), Lotrel
• amlodipine and atorvastatin (statin), Conduet
• amlodipine and celecoxib (nonsteroidal anti-inflammory drug), Consensai
• amlodipine and lisinopril (ACE inhibitor), Lisonorm
• amlodipine and olmesartan (ACE inhibitor), Azor
• amlodipine and valsartan (ACE inhibitor), Exforge
• amphetamine (stimulant, mixed salts of the racemic molecule) combining dextroamphetamine sulfate and D-amphetamine saccharate) with levoamphetamine sulfate and L-amphetamine aspartate monohydrate, Adderall by Shire Pharmaceuticals, MyDayis with slightly varying formulation; the precursor of these drugs was called Oby-Rex ( see below), combined D-amphetamine with methamphetamine, discontinued 1973
• bupropion (norepinephrine-dopamine reuptake inhibitor) and naltrexone (opioid receptor]] opioid antagonist), Contrave
• butalbital (barbiturate, CNS depressant) and caffeine (eugeroic), Butapap
• butalbital, caffeine, and aspirin (NSAID), Fiorinal
• butalbital, caffeine, and acetaminophen, Fioricet
• butalbital, caffeine, acetaminophen, and codeine (opioid), Fioricet with Codeine
• chlordiazepoxide (benzodiazepine) and clidinium bromide (anticholinergic), Librax⁵
• ephedrine (sympathomimetic) and ethylmorphine (opioid) Lephotan
• flupentixol (typical antipsychotic) and melitracen (tricyclic antidepressant), available outside of the U.S. as Deanxit by Lundbeck
• hydrocodone bitartrate (opioid agonist, tablet) and acetaminophen, Vicodin by AbbVie contains 325 mg acetaminophen as a tablet, currently the only brand form in the United States. Norco is a tablet containing 300 mg acetaminophen, with limited availability in select countries.⁶ LorTab by UCB is now an elixir avauilable in limited ountries⁷
• hydrocodone and aspirin, Azdone
• hydrocodone and guaifenesin (expectorant), Obedron, Flowtuss
• hydrocodone and ibuprofen (nonsteroidal anti-inflammatory]])NSAID), Ibudone
• ibuprofen and acetaminophen intravenous solution, Maxigesic IV⁸
• nirmatrelvir (antiviral) and ritonavir (antiviral), combination drug for treatment and management of COVID-19), Paxlovid⁹
• omeprazole (proton pump inhibitor), amoxicillin (antibiotic), and rifabutin (anti-tuberculosis), Talicia
• olanzapine (atypical antipsychotic) and fluoxetine (selective serotonin reuptake inhibitor), Symbyax
• oxycodone (opioid) and acetaminophen, Percocet
• oxycodone and aspirin, Percodan
• oxycodone and ibuprofen (nonsteroidal anti-flammatory), Combunol
• phentermine (substituted amphetamine, amphetamine derivative) and topiramate ([[antimigraine Qsymia by Vivus
• phenylephrine (sympathomimetic) and ketorolac (NSAID), Omidria¹⁰
• pseudoephedrine (sympathomimetic) and carbinoxamine (anticholinergic), Rondec elixir¹¹
• tramadol and paracetamol, Ultram

Combination drugs accessible over the counter (OTC)

Fixed-dose combination drugs for sale over the counter exist around the world, constituting doses that are tolerable to a mainstream consumer population. In the United States, items containing ephedrine, pseudoephedrine, or phenylpropanolamine can be purchased without a prescription, albeit under strict oversight and from behind the pharmacy counter, per the U.S. Federal drug law titled the Combat Methamphetamine Epidemic Act of 2005.¹²

Fixed-dose combination drugs for sale over the counter internationally, including medicine indicated for various purposes:

• aspirin and caffeine, Anacin by Bayer, tablet widely available since 1916¹³
• chlorpheniramine (first-generation antihistamine) and phenylpropanolamine (sympathomimetic), marketed as Vernate Injection by Tutag Pharmaceuticals, a liquid solution for intramuscular injection;¹⁴¹⁵¹⁶ available as the tablet Tri-Nefrin, and a syrup elixir Altec Syrup, all available in Asia, all discontinued in U.S. by 2007.
• Coricidin by Bayer, a line of cough medicine combining chlorpheniramine and dextromethorphan; chlorpheniramine, dextromethorphan, guaifenesin, and acetaminophen is Coricidin Cold + Cough; chlorpheniramine, phenylephrine, guaifenesin, and acetaminophen is Coricidin HBP High Blood Pressure¹⁷
• aspirin, caffeine, and acetaminophen, Excedrin by Bayer¹⁸
• diphenhydramine and 8-chlorotheophylline as an ionic bond produce the compound dimenhydrinate, Dramamine by GlaxoSmithKline.¹⁹²⁰
• fenproporex and diazepam, Esbelcaps available in Central and South America²¹
• fexofenadine and pseudoephedrine, Allegra-D by GlaxoSmithKline
• glucose, fructose and phosphoric acid, Emetrol for Nausea
• ibuprofen and famotidine (proton pump inhibitor), Duexis²²
• ibuprofen and diphenhydramine citrate, Advil PM
• loratadine and pseudoephedrine, Claritin-D by AstraZeneca
• naproxen sodium and diphenhydramine hydrochloride, Aleve PM by Bayer²³
• naproxen sodium and pseudoephedrine, Aleve-D
• Toplexil by Aventis, available in dosage forms including tablet, tincture, elixir and suppository, oxomemazine and guaifenesin, approved and available in France, Algeria, and Morocco²⁴
• Robitussin, a line of cough medicine encompassing various combinations including dextromethorphan, acetaminophen, chlorpheniramine, doxylamine succinate, and/or guaifenesin.
• guaifenesin and phenylephrine, Sudafed PE by Merck

Combination drugs under development

• MDmalopram methylenedioxymethamphetamine ("Molly" or "Ecstasy), an empathogen) and citalopram (SSRI), currently in FDA Phase II clinical trials²⁵ for treatment of post-traumatic stress disorder.

Combinations drugs for veterinary use

• Temaril-P combines alimemazine (antitussive) and prednisolone (antipruritic), suffix -P stands for "Pet" and is approved for use in dogs; has been a generic drug since 2024, and substitutes alimemazine for trimeprazine, leaving in place prednisolone, equivalent to branded formula in efficacy
• Titzeol combines tiletamine and zolazepam, tranquilizers to sedate large animals including elephants, giraffes, and rhinoceroses²⁶

Combination drugs no longer widely available

• Acutran by G.W. Carnrick Laboratories is composed of amfecloral, a compound molecule pairing dextroamphetamine sulfate and chloral hydrate,²⁷ discontinued 1973²⁸
• Ambar by Wyeth Pharmaceuticals combined methamphetamine hydrochloride and phenobarbital; Ambar Extentab was the extended-release formulation
• Amphaplex 10 by Laderle Laboratories (later acquired by Wyeth) combined 2.5 mg methamphetamine saccharate, 2.5 mg methamphetamine hydrochloride, and 5 mg racemic amphetamine sulfate; Amphaplex 20 combined 5 mg methamphetamine saccharate, 5 mg methamphetamine hydrochloride, and 10 mg racemic amphetamine sulfate.²⁹
• Amplus Now by Roehrig Laboratories combined 5 mg dextroamphetamine sulfate with 5 mg hydroxyzine (first-generation antihistamine)³⁰³¹
• Amvicel by Roehrig Laboratories combined 10 mg dextroamphetamine, 40 mg amobarbital, 15 mg phenobarbital, 30 mg nicotinamide, plus vitamins and essential minerals³²
• Apamead by Laderle Laboratories combined dextroamphetamine sulfate, amobarbital, aspirin, and phenacetin (racetin)
• ANOX by Winston Pharmaceuticals,encapsulated polypill combining a fixed dose of three barbiturate salts (20 mg each of phenobarbital, butabarbital, and secobarbital) and two amphetamine salts (7.5 mg each of methamphetamine hydrochloride and dextroamphetamine sulfate)³³
• Anxine by Behlen Manufacturing³⁴³⁵ combined 120 mg mephenesin (muscle relaxant), 35 mg cyclobarbital, and 2.5 mg dextroamphetamine sulfate
• Bama-Dex by Behlen Manufacturing combined 5 mg dextroamphetamine and 400 mg meprobamate³⁶
• Biphetamine T-12.5 and Biphetamine T-20 by Fisons comprised, respectively, 12.5 mg and 20 mg of racemic amphetamine salts, thereby containing the two enantiomers of racemic amphetamine, dextroamphetamine and levoamphetamine, at respective doses of 6.25 mg of each isomer for the former product, 10 mg of each for the latter.
• Bontril Timed No. 1 combined 2.5 mg dextroamphetamine and 7.5 mg butabarbital; Bontril Timed No. 2 5 mg dexamphetamine and 15 mg butabarbital; Bontril Timed No. 3 10 mg dexamphetamine and 30 mg butabarbital; Bontril Timed No. 4 15 mg dexamphetamine with 60 mg butabarbital, all manufactured and marketed by G.W. Carnrick Laboratories.³⁷
• Delcobese by Lemmon Drug Company was a balanced combination of racemic amphetamine sulfate and adipate, "withdrawn voluntarily in 1984, unrelated to safety or legal concerns"³⁸
• Desbutal by Irwin, Neisler & Co. (Neisler Labs), 5 mg methamphetamine and 30 mg pentobarbital, discontinued 1973³⁹
• Dexytal by Eli Lilly, combination dextroamphetamine and amobarbital elixir; Dexamyl by Smith, French & Kline (now GlaxoSmith Kline/GSK), dextroamphetamine and amobarbital as a tablet, discontinued 1982; Daprisal by GSK, dextroamphetamine, amobarbital, and aspirin as a tablet
• Durophet-M and Durabond, both by Neisler Labs: the former combined 12.5 mg amphetamine and 400 mg methaqualone (sedative-hypnotic), discontinued 1984 due to global convention banning methaqualone; Durabond, tablet combining 8 mg chlorpheniramine tannate (first-generation antihistamine/FGA), 25 mg pyrilamine tannate (first-generation antihistamine), and "10 mg Tanphetamin (racemic amphetamine tannate) [also by Neisler]""General Practice American Academy(20)". 1959.</ref>
• Direcel combined dextroamphetamine, butabarbital, carboxymethylcellulose; Direcel-T included additional thyroid hormone
• DuoDex combined aloin (laxative), dextroamphetamine, pentobarbital, and thyroid hormone
• Dysonil combined methamphetamine, pentobarbital, and salicylamide (analgesic)
• Edrisal combined 160 mg aspirin, 160 mg phenacetin, 2.5 mg amphetamine sulfate; Edrisal with Codeine included an additional 16 mg codeine
• Ethobral by Wyeth, Triple-Barbiturate Tablets quinalbarbitone sodium (rapid-acting barbiturate), butobarbitone (intermediate-acting barbiturate), and phenobarbital (long-acting)⁴⁰⁴¹
• Eskatrol by Smith, French & Kline combined dextroamphetamine and prochlorperazine (first-generation antipsychotic, discontinued 1981
• Euphoramin, 5 mg methamphetamine and 300 mg meprobamate, Euphoramin
• Lamital by Teva Pharmaceuticals combines acetaminophen, amobarbital, and methamphetamine
• Mandrax by Lemmon Drug Company, tablet comprising methaqualone and diphenhydramine (first-generation antihistamine), available in South Africa until 1993
• Mediatric by Janssen Pharmaceuticals combined two hormones (0.25 mg Premarin and 2.5 mg methyltestosterone) with 100 mg vitamin c, b vitamins, and 1 mg methamphetamine
• NalerTan by Neisler combined 12.5 mg dextroamphetamine tannate, 8 mg chlorpheniramine tannate, and 25 mg pyrilamine tannate (first-generation antihistamine) ⁴²⁴³
• dextroamphetamine, amobarbital, methylcellulose, and nutritional supplements, brandedNexorin
• Obocell by Neisler combined 5 mg dextroamphetamine phosphate and 25 mg methapyrilene phosphate (antihistamine); Obocell-TF was identical in composition with the addition of a high-viscosity methylcellulose supplement, also by Neisler and listed as "160 mg Nitrin on the label)⁴⁴
• Obetrol by Abbott Laboratories was a mixture of methamphetamine and dextroamphetamine salts, discontinued 1973,⁴⁵ later re-branded Oby-Rex, swapping methamphetamine for levoamphetamine, the (s) isomer of racemic amphetamine.
• Obolip combined dextroamphetamine, phenobarbital, choline, dimethionine, and methylcellulose
• Phelantin by Parke-Davis combined 100 mg phenytoin (anticonvulsant), 32 mg pentobarbital, and 2.5 mg methamphetamine⁴⁶
• Phenephen by A.H. Robins combined hyoscyamine sulfate, phenacetin, and aspirin; Phenephen with Codeine was the aforementioned formula with codeine as a fourth active ingredient
• Pondimin, better known as "fen-phen," a colloquialism for combination fenfluramine and phentermine, discontinued 1997⁴⁷
• SynaTan-S by Neisler (later acquired by Mallinckrodt and re-branded OboTan-S)⁴⁸⁴⁹⁵⁰) combined 10 mg dextroamphetamine tannate with 35 mg secobarbital⁵¹
• Pre M.T. by Behlen combined racemic amphetamine sulfate, pentobarbital, and pyrilamine maleate with a microdose of theobromine
• Reladorm combined 100 mg cyclobarbitol and 10 mg diazepam, last available in Russia until it was discontinued in 2019⁵²
• Tuinal by AbbVie was a capsule containing amobarbital and secobarbital (double barbiturate); voluntarily discontinued by AbbVie in 2008, citing widespread substance abuse as well as declining sales due to a decrease in prescriptions, and thus, demand.⁵³

Medical use and justification of discontinued combination drugs

Most of the combination drugs which have been discontinued since the twentieth century were simultaneously indicated and utilized for treatment of various conditions, with medical use justified as part of a multifaceted, comprehensive approach to patient health care and medical treatment. Central nervous system stimulants were versatile as anorectic, antidepressant, and eugeroic (wakefulness-promoting) agents, boosting mental alertness and physical stamina, as well as the ability to maintain focus and motivation. Theoretically, when combined with a CNS depressant, a stimulant's adverse effects (primarily overstimulation , paranoia, and/or anxiety) could be mitigated or reduced/balanced without eliminating the stimulant's therapeutic benefits. The stimulating component was almost always of the substituted amphetamine chemical class or an amphetamine derivative or analog; the tranquilizing component was either one or more barbiturate salts, or non-barbiturate GABAergic drugs (e.g. meprobamate, methaqualone) with a similar mechanism of action, with tranquilizing, muscle relaxant, and sedating effects.

Patients are empowered with the capability of alleviating symptoms of multiple medical conditions with the ingestion of a single dosage form, reducing the patient's pill burden and consistently showing improved medication compliance scores. The American Association of Orthodontists asserts that fixed-dose combinations "limit clinicians' ability to customize dosing regimens,"⁵⁴ despite conceding that these combinations were often capable of replacing Monoamine Oxidase Inhibitors (MAOIs) in patients with treatment-resistant depression where MAOI treatment is appropriate, but where the MAOI-related dietary restrictions would otherwise hinder patient compliance.

Scientists formulating combination drugs face challenges in the development stages of multi-drug formulations such as compatibility issues among active ingredients and excipients affecting solubility and dissolution⁵⁵ For prescribers, if one constituent of the combination is contraindicated for a patient, the product cannot be prescribed.⁵⁶⁵⁷

Limitations of currently-available combinations

The limitations of combination formulations currently available for treating a widely-inclusive collection of symptoms such as Tourette's is highlighted by there not being a polypill or any combination formula period approved for treating the condition. Medication available, and sometimes used in the context of polypharmacy involves various individual medicines for treating tics and/or generalized anxiety or social anxiety disorder and/or obsessive-compulsive anxieties with use of individual benzodiazepines or SSRIs for the former two conditions, and fluvoxamine or clomipramine first-line treatments for OCD and related disorders, such as hoarding or compulsive decluttering. But, where Attention-Deficit Hyperactivity Disorder, depression, or insomnia become a primary concern to the patient, it is only through polypharmacy (in this case, adding another antidepressant or a "booster, alongside a hypnotic soporific agent, and/or psychostimulants to both treat ADHD and counteract the sleep inertia, grogginess or hangover caused by the other evening medications).

Tourette syndrome is a neurological tic disorder for which treatment options are currently limited; only the typical antipsychotics, pimozide and haloperidol are specifically approved for treating the tic component of Tourette's;⁵⁸ clonidine and guanfacine are approved for ADHD, which often comorbid to Tourette's, but not necessarily guaranteed to reduce tics. Typically identified by chronic motor and vocal tics (described by NIH as "semi-voluntary" actions performed in response to a premonitory urge, an internal sensory phenomenon akin to a buildup of tension, only able to be alleviated upon releasing a tic.⁵⁹ Tourette's, however, is an all-encompassing umbrella term that presents not just as chronic motor/physical and vocal/phonic tics; tics are nearly always comorbid to symptoms of obsessive-compulsive anxiety and/or social anxiety, avoidant personality or schizoid personality, ADHD, as well as insomnia, depression, and traits of high-functioning autism (formerly "Asperger syndrome").

Illicit "street" drug combinations

So-called "powder cocaine" often contains stimulants meant to mimic cocaine's effects; many batches analyzed did not contain any cocaine or coca alkaloids at all; most frequently, "powder cocaine" is found to contain designer drugs and/or research chemicals including synthetic cathinones, MDMA, methamphetamine, caffeine, and increasingly the flesh-eating veterinary antibiotic levamisole have been found in "powder cocaine."⁶⁰

Since the forced closure of so many pill mills in the U.S. beginning in 2007, a black market for opioids has flourished and continuously expanded.⁶¹ As demand increases for relatively mild opioid "pain pills" ranging from codeine, hydrocodone, oxycodone, morphine, diacetylmorphine (Heroin) items being deceptively sold as such are adulterated by undeclared amounts of highly potent synthetic opioids of questionable purity. Prince died in April 2016 from taking pills he thought were "Percocet;" in actuality, the "Percocet" was not relatively mild oxycodone, but counterfeit "presses" or "pressed pills" that resulted in Prince's gradual ingestion of unknown, but lethal, quantities of fentanyl. "Presses" are synthesized via clandestine chemistry by untrained chemists and often cut with agents including fentanyl, carfentanil, and as of September 2024, nitazenes.⁶²⁶³

Other cutting agents increasingly found in illicit supplies include the veterinary drug xylazine and the designer drugs (synthetic triazolobenzodiazepines) bromazolam, clobromazolam, phenazolam, and flualprazolam.⁶⁴ In April 2025, U.S. Attorney General Pam Bondi stated a desire to regulate xylazine under U.S. federal drug law) as a Schedule III controlled substance.⁶⁵ Xylazine is currently a controlled substance under state statutes in Michigan and New York.⁶⁶

Mandrax is the trade name of a pharmaceutical combination drug consisting of methaqualone and diphenhydramine.,⁶⁷ once prescribed in South Africa, but banned in 1993. "Mandrax" is now synthesized via clandestine chemistry as a free base preparation, which is smoked for an intense, short-lived "high".⁶⁸

See also

• Codrugs
• Synergy#Drug synergy

External links

• Media related to Combination drugs at Wikimedia Commons

References

1. Martin, Mike (2009-04-01). "5-in-1 PolyPill Treatment May Prevent Heart Disease". www.bayviewrx.com. Archived from the original on 2014-02-27. https://web.archive.org/web/20140227164714/http://www.bayviewrx.com/bayview-blog/bid/18766/5-in-1-PolyPill-Treatment-May-Prevent-Heart-Disease ↩

2. Grobbee'], ['Diederick E. "Cardioprotective Drugs: Polypills".{{cite web}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link) https://www.escardio.org/Education/ESC-Prevention-of-CVD-Programme/Treatment-goals/Cardio-Protective-drugs/polypills ↩

3. "The Compounder - Amino Acids, Minerals, Nutrients & Vitamins". https://thecompounder.com/amino-acids-minerals-nutrients-vitamins/ ↩

4. "Antiretroviral Drug Discovery and Development". National Institutes of Health. 5 February 2024. Retrieved 2025-04-25. https://www.niaid.nih.gov/diseases-conditions/antiretroviral-drug-development ↩

5. https://www.goodrx.com/librax/what-is?srsltid=AfmBOoprJz8XcQ7jc0LGipTRE_p2TymM_psQ45Vj7iptkdP1gU3lDimO GoodRX: combination is generic for Librax https://www.goodrx.com/librax/what-is?srsltid=AfmBOoprJz8XcQ7jc0LGipTRE_p2TymM_psQ45Vj7iptkdP1gU3lDimO ↩

6. "Norco (Hydrocodone / Acetaminophen): Basics, Side Effects & Reviews". GoodRX. Retrieved June 26, 2025. https://www.goodrx.com/norco/what-is ↩

7. https://www.therecoveryvillage.com/lortab-addiction/lortab-vs-norco/#:~:text=Both%20Lortab%20and%20Norco%20contain,would%20be%20on%20their%20own Source distinguishing Vicodin, Norco, Lortab -- source may be biased as an addiction rehabilitation service https://www.therecoveryvillage.com/lortab-addiction/lortab-vs-norco/#:~:text=Both%20Lortab%20and%20Norco%20contain,would%20be%20on%20their%20own ↩

8. "Hyloris announces U.S. FDA Approval of Maxigesic® IV". 18 October 2023. https://www.biospace.com/hyloris-announces-u-s-fda-approval-of-maxigesic-iv ↩

9. "Paxlovid (nirmatrelvir tablets; ritonavir tablets) for HCPs". paxlovid.pfizerpro.com. Retrieved 2025-04-24. https://paxlovid.pfizerpro.com/?cmp=151381085882&utm_source=GOOGLE&utm_medium=paidsearch&pid=Paxlovid_GOOGLE_PPC_PAX_BR_HCP_CON_EXT_BRN_BRA_GM_ENG_E0002HW7_SEA_PP-C1D-USA-0766_7/5/2025&utm_campaign=20237500762&utm_content=1558510530848&utm_term=paxlovid%20healthcare&gad_source=1&gbraid=0AAAAAoVyGElVuCgDwcrr_fbvgzLnYrM8r&gclid=CjwKCAjwn6LABhBSEiwAsNJrjkBJQFczDwtAcISQTrOVFacq1ooUqcqWp46TN8FDFj4SgezvfPbo4xoCeVMQAvD_BwE&gclsrc=aw.ds ↩

10. "Promethazine (CHEBI:8461)". https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8461 ↩

11. "Rondec (Carbinoxamine Maleate and Pseudoephedrine HCl): Side Effects, Uses, Dosage, Interactions, Warnings". RxList. Retrieved 2025-04-24. https://www.rxlist.com/rondec-drug.htm ↩

12. "Diversion Control Division | CMEA (The Combat Methamphetamine Epidemic Act of 2005)". www.deadiversion.usdoj.gov. Retrieved 2025-04-24. https://www.deadiversion.usdoj.gov/meth/combat-methamphetamine-epidemic-act.html ↩

13. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=51ab0ee3-3c94-424d-a30a-2d6c14e3d8ff National Institute of Health FDA overview https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=51ab0ee3-3c94-424d-a30a-2d6c14e3d8ff ↩

14. "Chlorpheniramine and Phenylpropanolamine Drug Information - Indications, Dosage, Side Effects and Precautions". Medindia. Retrieved 2025-04-15. https://www.medindia.net/doctors/drug_information/chlorpheniramine_phenylpropanolamine.htm ↩

15. "Elvis Presley-Owned Prescription Bottle and Box (1976)". entertainment.ha.com. https://entertainment.ha.com/itm/music-memorabilia/memorabilia/elvis-presley-owned-prescription-bottle-and-box-1976-total-2-items-/a/7081-46290.s ↩

16. "JoDrugs. Vernate". www.jodrugs.com. Retrieved 2025-04-24. https://www.jodrugs.com/tradenames/167408-vernate.aspx ↩

17. "Label: Coricidin HBP Cold and Flu". DailyMed. December 30, 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=763a5334-a741-4678-9947-603776622450 ↩

18. "Aspirin and Dual Antiplatement Therapy". American Heart Association (AHA). Journal of the American Heart Association. Retrieved April 26, 2025. https://www.heart.org/en/health-topics/heart-attack/treatment-of-a-heart-attack/aspirin-and-heart-disease ↩

19. "Dimenhydrinate". National Institute of Diabetes and Digestive and Kidney Diseases. 2012. PMID 31643540. https://www.ncbi.nlm.nih.gov/books/NBK548215/ ↩

20. https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8461 "The anti-emetic action of both the hydrochloride and the teoclate (8-chlorotheophylline) salts is used for the prevention of nausea in cases of motion sickness and post-operative vomiting." https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8461 ↩

21. "Esbelcaps (International database)". Drugs.com. Retrieved 2025-04-24. https://www.drugs.com/international/esbelcaps.html ↩

22. "Duexis: Uses, Dosage & Side Effects". Drugs.com. Retrieved 2025-04-24. https://www.drugs.com/duexis.html ↩

23. "Aleve® Pm". https://www.aleve.com/products/aleve-pm ↩

24. "Oxomemazine". https://go.drugbank.com/drugs/DB13820 ↩

25. Michael Haichin (2024). "Psychedelics Drug Development Tracker". Psychedelic Alpha. Retrieved 29 January 2025. https://psychedelicalpha.com/data/psychedelic-drug-development-tracker ↩

26. "Minnesota Rules 2002 – Chapter 6800 – Board of Pharmacy – Pharmacy and Pharmacists". www.revisor.mn.gov. https://www.revisor.mn.gov/rules/6800/date/2002 ↩

27. "Carnrick Acquired by Irish Élan". Irish Times. Irish Times. April 23, 1998. Retrieved May 10, 2025. https://www.irishtimes.com/business/elan-agrees-to-buy-us-pharmaceutical-group-carnrick-in-deal-worth-107m-1.145286 ↩

28. Schmeck, Jr., Harold (June 15, 1973). "Curbs Placed on Appetite Suppressants". New York Times. Retrieved May 6, 2025. https://www.nytimes.com/1973/06/15/archives/curbs-placed-on-appetite-suppressants-drug-switches-cited-final.html. ↩

29. "Amphaplex 10 methamphetamine amphetamine Palmedics Bottle narcotic empty | #1825423307". Worthpoint. Retrieved 2025-04-24. https://www.worthpoint.com/worthopedia/amphaplex-10-methamphetamine-1825423307 ↩

30. Rasmussen, Nicolas (June 2008). "America's first amphetamine epidemic 1929-1971: a quantitative and qualitative retrospective with implications for the present". American Journal of Public Health. 98 (6): 974–985. doi:10.2105/AJPH.2007.110593. ISSN 1541-0048. PMC 2377281. PMID 18445805. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377281 ↩

31. "Side Effects of Anti-Obesity Drugs" (PDF). ia601401.us.archive.org. https://ia601401.us.archive.org/10/items/in.ernet.dli.2015.145028/2015.145028.Side-Effects-Of-Anti-Obesity-Drugs_text.pdf ↩

32. "Advertisement for Amvicel". The American Academy of General Practice: 410. 1959. Retrieved 2025-05-09. https://archive.org/details/in.ernet.dli.2015.116604/page/n409/mode/2up ↩

33. "Winston Pharmaceutical products". JO Drug Database. JO Drug Bank. Retrieved 2025-05-09. https://www.jodrugs.com/manufacturer/15200-winston-pharmaceutical.aspx ↩

34. Green, A. Richard; Aronson, Jeffrey K; Haddad, Peter M (2013). "Examining the 'psychopharmacology revolution' (1950–1980) through the advertising of psychoactive drugs in the British Medical Journal". Sage Journal of Psychopharmacology. 32 (10): 1056–1066. doi:10.1177/0269881118796810. PMID 30251594. Retrieved April 30, 2025. https://journals.sagepub.com/doi/10.1177/0269881118796810?icid=int.sj-full-text.similar-articles. ↩

35. Bartholomew, Arthur Allen (A.A.) (1970). "Amphetamine addiction". Medical Journal of Australia. 1 (24): 1209–1214. doi:10.5694/j.1326-5377.1970.tb84529.x. PMID 5451397. /wiki/Doi_(identifier) ↩

36. "international Naming Nomenclature" (PDF). UN Psychotropic Convention. 1971. https://free-ankara.org/wp-content/uploads/2016/02/1971_UN.pdf ↩

37. "Bontril Timed #1 by CARNRICK Laboratories". JODrugs. https://www.jodrugs.com/tradenames/53611-bontril-timed-no-1.aspx ↩

38. "Determination That Delcobese (L-Amphetamine and D-amphetamine Adipate, L-Amphetamine and D-amphetamine Sulfate) Tablets and Capsules Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness". No. Notice of FDA. Federal Register -- the Daily Journal of the U.S. Government. U.S. Food and Drug Administration. November 10, 2003. Retrieved 2025-05-10. https://www.federalregister.gov/documents/2003/11/10/03-28193/determination-that-delcobese-amphetamine-adipate-amphetamine-sulfate-dextroamphetamine-adipate ↩

39. Schmeck, Jr., Harold (June 15, 1973). "Curbs Placed on Appetite Suppressants". New York Times. Retrieved May 6, 2025. https://www.nytimes.com/1973/06/15/archives/curbs-placed-on-appetite-suppressants-drug-switches-cited-final.html. ↩

40. "Index to Volume V" (PDF). Journal of J.J. Group of Hospitals and Grant. 5 (N/A). Editorial Board of the Journal of J.J. Group of Hospitals & Grant Medical College: 94. 1960. Retrieved June 26, 2025. https://ia801401.us.archive.org/32/items/in.ernet.dli.2015.66888/2015.66888.Jouranal-Of-J-J-Group-Hospitals-And-Grant-Medical-College5_text.pdf ↩

41. "Prescription Pad: Hospital Topics -- ETHOBRAL". Hospital Topics. 32 (2): 5–6. 1954. doi:10.1080/00185868.1954.9951807. Retrieved June 27, 2025. https://www.tandfonline.com/doi/pdf/10.1080/00185868.1954.9951807 ↩

42. "Dextroamphetamine tannate". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-04-24. https://pubchem.ncbi.nlm.nih.gov/compound/Dextroamphetamine-tannate ↩

43. "Notices of Judgment Under the Federal Food, Drug, and Cosmetic Act" (PDF). upload.wikimedia.org. https://upload.wikimedia.org/wikipedia/commons/9/98/Notices_of_judgment_under_the_Federal_food%2C_drug%2C_and_cosmetic_act_...Drugs_and_devices_%28IA_CAT11088280015%29.pdf ↩

44. "Irwin Neisler & Co. File - File, Nail | Science History Institute". sciencehistory.pastperfectonline.com. Retrieved 2025-04-24. https://sciencehistory.pastperfectonline.com/webobject/4319798D-5DB1-4B3A-92E4-665749368298 ↩

45. Schmeck, Jr., Harold (June 15, 1973). "Curbs Placed on Appetite Suppressants". New York Times. Retrieved May 6, 2025. https://www.nytimes.com/1973/06/15/archives/curbs-placed-on-appetite-suppressants-drug-switches-cited-final.html. ↩

46. https://www.neurores.org/index.php/neurores/article/viewFile/356/345 precursor to Dilantin, sans pentobarbitone https://www.neurores.org/index.php/neurores/article/viewFile/356/345 ↩

47. Kolata, Gina (1997-09-23). "How Fen-Phen, A Diet 'Miracle,' Rose and Fell". The New York Times. ISSN 0362-4331. Retrieved 2025-04-24. https://www.nytimes.com/1997/09/23/science/how-fen-phen-a-diet-miracle-rose-and-fell.html ↩

48. "Pharmacy Drugstore Obotan Forte Dextroamphetamine Tannate Mallinckrodt". Worthpoint. Retrieved 2025-04-24. https://www.worthpoint.com/worthopedia/pharmacy-drugstore-obotan-forte-292341330 ↩

49. https://pubchem.ncbi.nlm.nih.gov/compound/Dextroamphetamine-tannate chemical name of dexamfetamine tannate https://pubchem.ncbi.nlm.nih.gov/compound/Dextroamphetamine-tannate ↩

50. Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 368 ↩

51. "Encyclopedia of international pharmaceutical registrations" (PDF). Vietnamese National University Encyclopedia of Medicine: 4132. 2009. Retrieved 2025-05-09. http://danida.vnu.edu.vn/cpis/files/Encyclo_Al/l/15265_v04_04.pdf ↩

52. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Nar/cotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16. /wiki/Brazilian_Health_Regulatory_Agency ↩

53. "You know you're getting old when…………". 13 February 2011. https://gpug.wordpress.com/2011/02/13/you-know-youre-getting-old-when/ ↩

54. "Glaucoma Medical Therapy-Principles and Management" (PDF). www.oculist.net. http://www.oculist.net/downaton502/prof/ebook/glaucoma/GlaucomaMedicalTherapy.pdf#page=162 ↩

55. Mitra, Amitava; Wu, Yunhui (September 2012). "Challenges and Opportunities in Achieving Bioequivalence for Fixed-Dose Combination Products". The AAPS Journal. 14 (3): 646–655. doi:10.1208/s12248-012-9378-x. ISSN 1550-7416. PMC 3385830. PMID 22684403. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385830 ↩

56. Kennedy Seele, 2020 November 12 ↩

57. Lee, GB; Hosking, SM; Etherton-Beer, C; Pasco, JA; Williams, LJ; Holloway-Kew, K; Page, AT (February 2025). "Defining polypharmacy in older adults: a cross-sectional comparison of prevalence estimates calculated according to active ingredient and unique product counts". International Journal of Clinical Pharmacy. 47 (3): 824–833. doi:10.1007/s11096-025-01882-7. PMC 12125127. PMID 39954222. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125127 ↩

58. "Pimozide (Oral route)". Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/pimozide-oral-route/description/drg-20065529 ↩

59. https://pmc.ncbi.nlm.nih.gov/articles/PMC7289498/ National Institutes of Health -- Premonitory Urge phenomenon as a related to the compulsion to tic in obsessive-compulsive anxiety stemming from Tourette's https://pmc.ncbi.nlm.nih.gov/articles/PMC7289498/ ↩

60. "Cocaine Laced With Veterinary Drug Levamisole Eats Away at Flesh". ABC News. Retrieved 2025-04-24. https://abcnews.go.com/Health/Wellness/flesh-eating-cocaine-laced-veterinary-drug-levamisole/story?id=13902353 ↩

61. "Punishing Pill Mill Doctors". William & Mary Press. 2018. Retrieved 2025-05-10. https://scholarship.law.wm.edu/cgi/viewcontent.cgi?article=3056&context=facpubs ↩

62. "News: February 2025 – UNODC EWA: Increasing availability of nitazenes calls for global response". www.unodc.org. Retrieved 2025-04-24. https://www.unodc.org/LSS/Announcement/Details/b47cf39e-f557-4001-98a8-536af5673e9e ↩

63. https://www.oas.org/ext/DesktopModules/MVC/OASDnnModules/Views/Item/Download.aspx?type=1&id=1045&lang=1 Sep 2024 Nitazenes in the Supply of Pressed Counterfeit Pills https://www.oas.org/ext/DesktopModules/MVC/OASDnnModules/Views/Item/Download.aspx?type=1&id=1045&lang=1 ↩

64. https://www.cfsre.org/images/content/reports/public_alerts/Public-Alert_Bromazolam_NPS-Discovery_061522.pdf Public Alert on Bromazolam and Fentanyl https://www.cfsre.org/images/content/reports/public_alerts/Public-Alert_Bromazolam_NPS-Discovery_061522.pdf ↩

65. "Xylazine: What Clinicians Need to know" (PDF). New York State Department of Health. https://www.health.ny.gov/publications/12044.pdf ↩

66. "Xylazine". Diversion Control Division. Retrieved 2025-04-24. https://www.deadiversion.usdoj.gov/drug_chem_info/xylazine/xylazine.html ↩

67. https://www.ojp.gov/pdffiles1/Digitization/117274NCJRS.pdf Page 79 describes Mandrax and its Schedule I status in the U.S. also including a photograph of the pharmaceutical-grade tablet https://www.ojp.gov/pdffiles1/Digitization/117274NCJRS.pdf ↩

68. South Africa - a Profile of the Drug Trade (PDF). United Nations. pp. 1–3. Retrieved 2025-05-10. https://www.unodc.org/pdf/southafrica/country_profile_southafrica_3.pdf ↩