Isotopes of gallium - Reference.org

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Isotopes of gallium

Natural gallium (31Ga) consists of a mixture of two stable isotopes: gallium-69 and gallium-71. Twenty-nine radioisotopes are known, all synthetic, with atomic masses ranging from 60 to 89; along with three nuclear isomers, 64mGa, 72mGa and 74mGa. Most of the isotopes with atomic mass numbers below 69 decay to isotopes of zinc, while most of the isotopes with masses above 71 decay to isotopes of germanium. Among them, the most commercially important radioisotopes are gallium-67 and gallium-68.

Gallium-67 (half-life 3.3 days) is a gamma-emitting isotope (the gamma ray emitted immediately after electron capture) used in standard nuclear medical imaging, in procedures usually referred to as gallium scans. It is usually used as the free ion, Ga3+. It is the longest-lived radioisotope of gallium.

The shorter-lived gallium-68 (half-life 68 minutes) is a positron-emitting isotope generated in very small quantities from germanium-68 in gallium-68 generators or in much greater quantities by proton bombardment of 68Zn in low-energy medical cyclotrons, for use in a small minority of diagnostic PET scans. For this use, it is usually attached as a tracer to a carrier molecule (for example the somatostatin analogue DOTATOC), which gives the resulting radiopharmaceutical a different tissue-uptake specificity from the ionic 67Ga radioisotope normally used in standard gallium scans.

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List of isotopes

Nuclide³	Z	N	Isotopic mass (Da)⁴ ⁵ ⁶	Half-life ⁷	Decaymode ⁸ ⁹	Daughterisotope ¹⁰	Spin andparity ¹¹ ¹² ¹³	Natural abundance (mole fraction)
Nuclide³	Excitation energy			Half-life ⁷	Decaymode ⁸ ⁹	Daughterisotope ¹⁰	Spin andparity ¹¹ ¹² ¹³	Normal proportion¹⁴	Range of variation
60Ga	31	29	59.95750(22)#	72.4(17) ms	β+ (98.4%)	60Zn	(2+)
					β+, p (1.6%)	59Cu
					β+, α? (<0.023%)	56Ni
61Ga	31	30	60.949399(41)	165.9(25) ms	β+	61Zn	3/2−
61Ga	31	30	60.949399(41)	165.9(25) ms	β+, p? (<0.25%)	60Cu	3/2−
62Ga	31	31	61.94418964(68)	116.122(21) ms	β+	62Zn	0+
63Ga	31	32	62.9392942(14)	32.4(5) s	β+	63Zn	3/2−
64Ga	31	33	63.9368404(15)	2.627(12) min	β+	64Zn	0(+#)
64mGa	42.85(8) keV			21.9(7) μs	IT	64Ga	(2+)
65Ga	31	34	64.93273442(85)	15.133(28) min	β+	65Zn	3/2−
66Ga	31	35	65.9315898(12)	9.304(8) h	β+	66Zn	0+
67Ga¹⁵	31	36	66.9282023(13)	3.2617(4) d	EC	67Zn	3/2−
68Ga¹⁶	31	37	67.9279802(15)	67.842(16) min	β+	68Zn	1+
69Ga	31	38	68.9255735(13)	Stable			3/2−	0.60108(50)
70Ga	31	39	69.9260219(13)	21.14(5) min	β− (99.59%)	70Ge	1+
70Ga	31	39	69.9260219(13)	21.14(5) min	EC (0.41%)	70Zn	1+
71Ga	31	40	70.92470255(87)	Stable			3/2−	0.39892(50)
72Ga	31	41	71.92636745(88)	14.025(10) h	β−	72Ge	3−
72mGa	119.66(5) keV			39.68(13) ms	IT	72Ga	(0+)
73Ga	31	42	72.9251747(18)	4.86(3) h	β−	73Ge	1/2−
73mGa	0.15(9) keV			<200 ms	IT?	73Ga	3/2−
73mGa	0.15(9) keV			<200 ms	β−	73Ge	3/2−
74Ga	31	43	73.9269457(32)	8.12(12) min	β−	74Ge	(3−)
74mGa	59.571(14) keV			9.5(10) s	IT (>75%)	74Ga	(0)(+#)
74mGa	59.571(14) keV			9.5(10) s	β−? (<25%)	74Ge	(0)(+#)
75Ga	31	44	74.92650448(72)	126(2) s	β−	75Ge	3/2−
76Ga	31	45	75.9288276(21)	30.6(6) s	β−	76Ge	2−
77Ga	31	46	76.9291543(26)	13.2(2) s	β−	77mGe (88%)	3/2−
77Ga	31	46	76.9291543(26)	13.2(2) s	β−	77Ge (12%)	3/2−
78Ga	31	47	77.9316109(11)	5.09(5) s	β−	78Ge	2−
78mGa	498.9(5) keV			110(3) ns	IT	78Ga
79Ga	31	48	78.9328516(13)	2.848(3) s	β− (99.911%)	79Ge	3/2−
79Ga	31	48	78.9328516(13)	2.848(3) s	β−, n (0.089%)	78Ge	3/2−
80Ga	31	49	79.9364208(31)	1.9(1) s	β− (99.14%)	80Ge	6−
80Ga	31	49	79.9364208(31)	1.9(1) s	β−, n (.86%)	79Ge	6−
80mGa¹⁷	22.45(10) keV			1.3(2) s	β−	80Ge	3−
					β−, n?	79Ge
					IT	80Ga
81Ga	31	50	80.9381338(35)	1.217(5) s	β− (87.5%)	81mGe	5/2−
81Ga	31	50	80.9381338(35)	1.217(5) s	β−, n (12.5%)	80Ge	5/2−
82Ga	31	51	81.9431765(26)	600(2) ms	β− (78.8%)	82Ge	2−
					β−, n (21.2%)	81Ge
					β−, 2n?	80Ge
82mGa	140.7(3) keV			93.5(67) ns	IT	82Ga	(4−)
83Ga	31	52	82.9471203(28)	310.0(7) ms	β−, n (85%)	82Ge	5/2−#
					β− (15%)	83Ge
					β−, 2n?	81Ge
84Ga	31	53	83.952663(32)	97.6(12) ms	β− (55%)	84Ge	0−#
					β−, n (43%)	83Ge
					β−, 2n (1.6%)	82Ge
85Ga	31	54	84.957333(40)	95.3(10) ms	β−, n (77%)	84Ge	(5/2−)
					β− (22%)	85Ge
					β−, 2n (1.3%)	83Ge
86Ga	31	55	85.96376(43)#	49(2) ms	β−, n (69%)	85Ge
					β−, 2n (16.2%)	84Ge
					β− (15%)	86Ge
87Ga	31	56	86.96901(54)#	29(4) ms	β−, n (81%)	86Ge	5/2−#
					β−, 2n (10.2%)	85Ge
					β− (9%)	87Ge
88Ga¹⁸	31	57	87.97596(54)#		β−?	88Ge
88Ga¹⁸	31	57	87.97596(54)#		β−, n?	87Ge
89Ga¹⁹	31	58
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Gallium-67

Gallium-67 (67Ga) has a half-life of 3.26 days and decays by electron capture and gamma emission (in de-excitation) to stable zinc-67. It is a radiopharmaceutical used in gallium scans (alternatively, the shorter-lived gallium-68 may be used). This gamma-emitting isotope is imaged by gamma camera.

Gallium-68

Gallium-68 (68Ga) is a positron emitter with a half-life of 68 minutes, decaying to stable zinc-68. It is a radiopharmaceutical, generated in situ from the electron capture of germanium-68 (half-life 271 days) owing to its short half-life. This positron-emitting isotope can be imaged efficiently by PET scan (see gallium scan); alternatively, the longer-lived gallium-67 may be used. Gallium-68 is only used as a positron emitting tag for a ligand which binds to certain tissues, such as DOTATOC and DOTATATE,²⁰ which are somatostatin analogues useful for imaging neuroendocrine tumors. Gallium-68 DOTA scans are increasingly replacing octreotide scans (a type of indium-111 scan using octreotide as a somatostatin receptor ligand). The 68Ga is bound to a chemical such as DOTATOC and the positrons it emits are imaged by PET-CT scan. Such scans are useful in locating neuroendocrine tumors and pancreatic cancer.²¹ Thus, octreotide scanning for NET tumors is being increasingly replaced by gallium-68 DOTATOC scan.²²

References

Kumlin, J; Dam, J; Langkjaer, N; Chua, C.J.; Borjian, S.; Kassaian, A; Hook, B; Zeisler, S; Schaffer, P; Helge, Thisgaard (October 2019). "Multi-Curie Production of Ga-68 on a Biomedical Cyclotron". Conference: EANM'19. Retrieved 13 December 2019. https://www.researchgate.net/publication/336589918 ↩
Thisgaard, Helge; Kumlin, Joel; Langkjær, Niels; Chua, Jansen; Hook, Brian; Jensen, Mikael; Kassaian, Amir; Zeisler, Stefan; Borjian, Sogol; Cross, Michael; Schaffer, Paul (2021-01-07). "Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE". EJNMMI Radiopharmacy and Chemistry. 6 (1): 1. doi:10.1186/s41181-020-00114-9. ISSN 2365-421X. PMC 7790954. PMID 33411034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790954 ↩
mGa – Excited nuclear isomer. /wiki/Nuclear_isomer ↩
Wang, Meng; Huang, W.J.; Kondev, F.G.; Audi, G.; Naimi, S. (2021). "The AME 2020 atomic mass evaluation (II). Tables, graphs and references*". Chinese Physics C. 45 (3): 030003. doi:10.1088/1674-1137/abddaf. /wiki/Doi_(identifier) ↩
( ) – Uncertainty (1σ) is given in concise form in parentheses after the corresponding last digits. ↩
# – Atomic mass marked #: value and uncertainty derived not from purely experimental data, but at least partly from trends from the Mass Surface (TMS). ↩
Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S.; Audi, G. (2021). "The NUBASE2020 evaluation of nuclear properties" (PDF). Chinese Physics C. 45 (3): 030001. doi:10.1088/1674-1137/abddae. https://www-nds.iaea.org/amdc/ame2020/NUBASE2020.pdf ↩
Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S.; Audi, G. (2021). "The NUBASE2020 evaluation of nuclear properties" (PDF). Chinese Physics C. 45 (3): 030001. doi:10.1088/1674-1137/abddae. https://www-nds.iaea.org/amdc/ame2020/NUBASE2020.pdf ↩
Modes of decay: EC:Electron captureIT:Isomeric transitionn:Neutron emissionp:Proton emission /wiki/Electron_capture ↩
Bold symbol as daughter – Daughter product is stable. ↩
Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S.; Audi, G. (2021). "The NUBASE2020 evaluation of nuclear properties" (PDF). Chinese Physics C. 45 (3): 030001. doi:10.1088/1674-1137/abddae. https://www-nds.iaea.org/amdc/ame2020/NUBASE2020.pdf ↩
( ) spin value – Indicates spin with weak assignment arguments. ↩
# – Values marked # are not purely derived from experimental data, but at least partly from trends of neighboring nuclides (TNN). ↩
Kondev, F. G.; Wang, M.; Huang, W. J.; Naimi, S.; Audi, G. (2021). "The NUBASE2020 evaluation of nuclear properties" (PDF). Chinese Physics C. 45 (3): 030001. doi:10.1088/1674-1137/abddae. https://www-nds.iaea.org/amdc/ame2020/NUBASE2020.pdf ↩
Deexcitation gamma used in medical imaging /wiki/Gallium_scan ↩
Medically useful radioisotope /wiki/Radioisotope ↩
Order of ground state and isomer is uncertain. ↩
Shimizu, Y.; Kubo, T.; Sumikama, T.; Fukuda, N.; Takeda, H.; Suzuki, H.; Ahn, D. S.; Inabe, N.; Kusaka, K.; Ohtake, M.; Yanagisawa, Y.; Yoshida, K.; Ichikawa, Y.; Isobe, T.; Otsu, H.; Sato, H.; Sonoda, T.; Murai, D.; Iwasa, N.; Imai, N.; Hirayama, Y.; Jeong, S. C.; Kimura, S.; Miyatake, H.; Mukai, M.; Kim, D. G.; Kim, E.; Yagi, A. (8 April 2024). "Production of new neutron-rich isotopes near the N = 60 isotones Ge 92 and As 93 by in-flight fission of a 345 MeV/nucleon U 238 beam". Physical Review C. 109 (4): 044313. doi:10.1103/PhysRevC.109.044313. /wiki/Doi_(identifier) ↩
Shimizu, Y.; Kubo, T.; Sumikama, T.; Fukuda, N.; Takeda, H.; Suzuki, H.; Ahn, D. S.; Inabe, N.; Kusaka, K.; Ohtake, M.; Yanagisawa, Y.; Yoshida, K.; Ichikawa, Y.; Isobe, T.; Otsu, H.; Sato, H.; Sonoda, T.; Murai, D.; Iwasa, N.; Imai, N.; Hirayama, Y.; Jeong, S. C.; Kimura, S.; Miyatake, H.; Mukai, M.; Kim, D. G.; Kim, E.; Yagi, A. (8 April 2024). "Production of new neutron-rich isotopes near the N = 60 isotones Ge 92 and As 93 by in-flight fission of a 345 MeV/nucleon U 238 beam". Physical Review C. 109 (4): 044313. doi:10.1103/PhysRevC.109.044313. /wiki/Doi_(identifier) ↩
Chauhan, Aman; El-Khouli, Riham; Waits, Timothy; Agrawal, Rohitashva; Siddiqui, Fariha; Tarter, Zachary; Horn, Millicent; Weiss, Heidi; Oates, Elizabeth; Evers, B. Mark; Anthony, Lowell (2020-08-11). "Post FDA approval analysis of 200 gallium-68 DOTATATE imaging: A retrospective analysis in neuroendocrine tumor patients". Oncotarget. 11 (32): 3061–3068. doi:10.18632/oncotarget.27695. ISSN 1949-2553. PMC 7429177. PMID 32850010. https://www.oncotarget.com/article/27695/text/ ↩
Hofman, M.S.; Kong, G.; Neels, O.C.; Eu, P.; Hong, E.; Hicks, R.J. (2012). "High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours". Journal of Medical Imaging and Radiation Oncology. 56 (1): 40–47. doi:10.1111/j.1754-9485.2011.02327.x. PMID 22339744. S2CID 21843609. https://doi.org/10.1111%2Fj.1754-9485.2011.02327.x ↩
Scott, A, et al. (2018). "Management of Small Bowel Neuroendocrine Tumors". Journal of Oncology Practice. 14 (8): 471–482. doi:10.1200/JOP.18.00135. PMC 6091496. PMID 30096273. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091496 ↩

List of isotopes

Gallium-67

Gallium-68

See also

References